As RA said, the CPAP machines are very portable - easier to carry than a laptop. I've had absolutely no problem with the TSA. It's listed on their website as an approved medical device. You do have to take it out of the carrying case to send it through, just like a laptop. And it doesn't count toward your carry on bag limit since it's a licensed medical device. I carry a copy of the prescription with me, but I've never been asked to show it. The TSA seems to know exactly what it is. For traveling, I bought a longer hose than what is normally supplied since you never know what the layout of the bed/nightable, etc. will be and this gives you more configuration options. Also, you will need to buy distilled/purified water for the humidifier when you get to destination. Most hotel vending machines have water bottles, which is handy if you arrive late. I was worried about traveling with it before my first trip but it really is a no brainer. You could put it in your checked luggage, but you of course risk damage, theft, or lost delayed bag.